மீ டூ காலம்! என்னடி எப்படி இருக்க? (50)

Corona virus in India! Big mistake!

Indians seem to think, it is all over and that we outfought the virus! Not many cases around us, they say! People are making fun if someone is wearing a mask!!

The problem is..

It happened in Italy, Spain. It went up and came down for few months. After a break the second infection started much more aggressively. It killed much more people than people got killed during the first infection.

Same thing happened in France!

Same thing happened in USA!

Same thing  happened in UK! 

Germany, Russia! 

That's the trend we saw. 

India is not an exception to that?!

People in India "overlooking" that. Reason could be for survival. It is hard to shut down everything and live. It is impossible? If that is the case, I understand.

If you think that it is over. Then you are making a big mistake!

It is quite possible India will have a HUGE number of cases and DEATHS soon. I wish I am wrong!

It is your life! Live happily or die "bravely"!

Who am I to advise you to live or die?!! Yeah, it is your life!

--------------------------------

"என்னடி கரோ! எப்படி இருக்க?"

"போடா!"

"What?"

"Ha ha ha"

" How did you learn Tamil, bitch?"

 "Vani taught me"

"That bitch!"

"Dont call everyone as bitch. Your bitch is just me" 

" What else she taught you?"

"She taught me how to keep love life interesting"

"How is that?"

 "I cant reveal everything to you. It is between girls."

"You talk about sex with her?"

"Ha ha ha"

"I can never talk about sex with another guy. It is impossible"

"Really?!! Why?"

"I dont know. Is that weird?"

I dont know. Probably not"

"What did she taught you?" 

"She explained me why Indian marriages are not breaking and such"

"Ha Ha ha. Thats funny"

"It is not"

"That was history, Caro. WAKE UP!  It is all fucked up now!"

"Really?" 

" Today, everything got fucked up in India. Once women got financial independence in India, Indian marriages are fragile. Women want to be fooling around, drink, smoke just like fucking men. "

"Why?"

"They earned their financial freedom you see! They try making a good contribution to fuck up the Indian culture. Honestly marrying a white chick would be better than marrying a half-baked Indian bimbo"

"Oh, that's why you are behind my ass?"

"Of course, now you have got a reason for dumping me?"

"Fuck you!"

"I have a question"

"About Vani?"

"No, it is about biology"

"What?"

"Lately there is a conspiracy theory that Covid-19 is a man-made virus"

"Ha Ha Ha Made in China. Right?"

"The chinese say it was made in USA. Let us not worry about that. How do you make a virus in the lab?"

"Good question!"

"I want answer bitch!"

"I really dont know whether they will make it from a scratch or mutate another virus"

"I tried to look it up. It is unclear to me"

"I think they try to introduce few harmful genes in a virus"

"I see. Let us see the russian vaccine Sputnik V"

"Sputnik V?"

"Did you know the Russian vaccine works well and people in the west now accepting that Russian did not lie about it?"

"Really?"

"There was an article in British journal or something?"

"Who said that?"

"READ THIS!"

The Russian coronavirus vaccine, Sputnik V, was 92 percent effective at preventing symptomatic illness in a large clinical trial, robust protection that puts it in line with top vaccines developed in the United States and Europe, according to results published in a peer-reviewed journal Tuesday.

 "So? It works?"

"Thats what the experts say now!"

"It really does work?"

"Yes, it does Caro! Any way, let me get to the point. You know Sputnik vaccine has AD-23 and ADS and both of them are harmless viruses"

"Right?"

"They added the gene which can make the spike protein of Covid-19 into the genome of AD-23 and ADS" 

"So?"

"OK, Can I say,  AD-23 and ADS are now genetically modified viruses? Does it make any sense?"

"It does"

"The same strategy can be used to make new "Covid-19"!"

'Nobody has any proof supporting that man-made virus claim"

"Idk, some people believe it was made in China. Some scientist from west believe"

"It does not matter. We have to get the vaccine and we got"

"Did you get your second dose of pfizer vaccine?"

"Tomorrow"

"You might get mild fever?"

"Did you get?"

"No, I did not. My upper arm was sore, thats all"

"Then why would I get fever for the second dose?"

"Most of the people get fever, Caro"

"Why did not you get?"

"You know what? I strongly believe I got infected by Covid-19 in the very beginning itself?"

"When?"

"I think this virus was around from Jan 2020. We started realizing only in the beginning of March 2020"

"If you were infected already?"

"If I was infected by this virus already, my immune system already dealt with spike protein and it is not new to my immune system. So, Vaccine might not have a huge effect"

"Idk, it is hard to say"

"Indians claim they achieved herd immunity"

"Really? Is it possible?"

"I think it is quite possible. It is hard to control the spread of virus in India They are trying to justify why they have less cases unlike west"

"So ? Indian has achieved herd immunity?"

"Idk, Caro. We have to wait and see.It is puzzling to me. No matter what, we cant do anything about it."

"Right!"

"Why dont you invite the chick, Vani?"

"Why?"

"I want to tell her not to lie to you about how great Indian culture is"

"So? You want to take her on, and harass her?"

"NO! I just want to open her eyes and  see the world"

"No, I am not going to introduce her to you!"

"Why?"

"Because you may annoy her and she will break up my friendship"

"Come on!"

-to be continued

Relax please

மீ டூ காலம்! என்னடி எப்படி இருக்க? (49)

இந்தியாவின் கோவாக்சின்!

நான் நினைத்ததுபோல் அல்லாமல் இந்தியாவும் ஒரு கொரோனா வைரஸ் வாக்சின் தயாரிச்சு, வெளியிட தயாராகியுள்ளார்கள்.

 இந்தியன் வாக்சின் எப்படி இந்த வைரஸ்க்கு எதிரா வேலை செய்யுது. இல்லைனா வைரஸ்க்கு எதிரா எப்படி எதிர்ப்பு சக்தி உண்டாக்குது?

 இது   ஃபைசர், மெடொர்னா மாதிரி m-RNA  டெக்னாலஜியா?

இல்லை!

இது ரஸ்யாவின் ஸ்பட்னிக் அல்லது  ஆக்ஸ்ஃபோர்ட் வாக்சின் போல ஸ்பைக் ப்ரோட்டீன் சுமந்து வரும் அடினோவைரஸ் டெக்னாலஜியா?

இல்லை!

கோவாக்சின் என்ன பயோ டெக்னாலஜி வகையை சேர்ந்தது?

சைனாவில் தயாரித்த வாக்சின் போன்றது. அதாவது வீரியமில்லாத (கொல்லப்பட்ட) கொரோனா வைரஸ்தான் இந்த வாக்சின். வைரஸ்  கொல்லப்பட்டு இருந்தாலும், அதில் உள்ள பயோ மாலிக்கூல் (ஸ்பைக் ப்ரோட்டீன் உள்பட) எல்லாம் உயிரோட இருக்கலாம். அதை நம் உடலில் செலுத்தும்போது, அதற்கு எதிர்ப்பு சக்தி உண்டாகும்..

 பி பி சி ல இருந்து எடுக்கப்பட்டது கீழே

How does Covaxin work?

The homegrown government-backed vaccine has been developed by Bharat Biotech, a 24-year-old vaccine maker, which has a portfolio of 16 vaccines and exports to 123 countries.

It is an inactivated vaccine which means that it is made up of killed coronaviruses, making it safe to be injected into the body. Bharat Biotech used a sample of the coronavirus, isolated by India's National Institute of Virology.

When administered, immune cells can still recognise the dead virus, prompting the immune system to make antibodies against the pandemic virus.

 

 

The two doses are given four weeks apart. The vaccine can be stored at 2C to 8C.

Bharat Biotech says it has a stockpile of 20 million doses of Covaxin, and is aiming to make 700 million doses out of its four facilities in two cities by the end of the year. 

 

What is the controversy around Covaxin?

It all began when the regulator said the vaccine had been approved for "restricted use in emergency situations in public interest as an abundant precaution, in clinical trial mode, especially in the context of infection by mutant strains".

Experts wondered how a vaccine was cleared for emergency use by millions of vulnerable people when its trials were still underway.

Both the manufacturer and drug regulator say Covaxin is "safe and provides a robust immune response".

But the All India Drug Action Network said it was "baffled to understand the scientific logic" to approve "an incompletely studied vaccine". It said that there were "intense concerns arising from the absence of the efficacy data".

Bharat Biotech has defended the approval, saying Indian clinical trial laws allowed "accelerated" authorisation for use of drugs after the second phase of trials for "unmet medical needs of serious and life-threatening diseases in the country". It has promised to provide efficacy data for the vaccine by February. 

 

-----------------------------------------

 கதைக்கு தாவுவோம்!

 "You want to taste Cyanide and live?!"

"Live? You mean die!!"

"Of course you can live, Caro!"

"Really? How?'

"You can take very little Cyanide ion (CN-), not in the form or sodium or potassium cyanide (Na+  -CN or K+  -CN) but in a different form, and live"

"How can I do that?"

"Have you ever eaten apple seeds while eating apple?"

"Not really"

"Very careful, huh?"

 "Ha ha ha"

"It tastes somewhat bitter.I have eaten apple seeds."

"Seriously?"

"YES, It is ok to eat few seeds. Apple seeds have a compound which releases cyanide ion slowly"

"Slowly?"

"Yeah, it is an Organic compound with a CN group in it,  which can degrade in our stomach (you have HCl there), and release -CN ion"

"It wont kill me?"

"It releases very little amount of cyanide, not like KCN or NaCN or HCN. If you eat grams of apple seed, then only cyanide can kill you! Thats very unlikely"

"It can really kill me if I eat a lot of apple seeds"

"YES,  IT WILL, Caro!"

"How does cyanide ion kill us, anyway?"

"I think it sort of making strong complex with Fe2+ ion in hemoglobin, where usually oxygen binds and CN, does not allow oxygen to bind on it. Carbon monoxide does the same. So, Hemoglobin can not carry oxygen to our cells because cyanide took the spot of Oxygen and, so cells will not live without oxygen. When our cells die, we will die too"

"Seriously?"

"I strongly believe that is how it kills us. You must have studied, Right?"

"I don't study like Chemists do" 

"Anyway, Cyanide ion is the one which causes trouble. You can get that in several different sources. It is all about love"

"Ha ha ha, love?"

"Yeah, Fe2+ ion in our Hemoglobin loves Cyanide ion more than Oxygen molecule. And they form a strong bond and so, poor oxygen can not bind. That eventually kills us"

"What do we got in Apple seeds you said?" 

"It is called Amygdalin. It has couple of glucose molecules and a cyanide group as well"

"Hmm"

"Hmm what?"

 

"You are weird. "

"I am not."

 "Why do you do such research now?"

 "Learning about anything is always good, Caro. Especially when we have the background to learn. Anyway, that is what really happening. Do you know bitter Almond is bad for you if you eat a lot?"

"What does it has?"

"Hydrogen cyanide, they say. Actually it also has Amygdalin which generates the -CN, just like apple seeds"

 

 ********************

"Shall we talk about living?"

"OK, Darling. Do you know, Phillip Rivers?"

"The Charger's Quarter back?"

"He was with Chargers. He recently played for Indianapolis Colts"

"What about him?"

"He is retiring."

"Good for him"

" You know how many children he has?"

"How many?"

"Nine!"

"Seriously"

"He has a beautiful family"

 "It is indeed a beautiful family"

******************

"Did you get your shot? The PFIZER vaccine?"

"Yeah! I did"

"How did you feel? Any fever?"

"It was kind of mildly sore in my arm. I did not get any fever though"

"Me neither but the second dose will give you mild fever"

"Really?. Is that a larger amount of mRNA?"

"Apparently not. It is exactly same amount of same dose . 0.3 mL of that solution, but Idk the concentration of mRNA. I think our immune system is already awake because of first dose. Now the second dose will make it to fight hard,which might give you a mild fever"

"I dont want fever"

"It will be very mild, Caro. Dont worry"

"Do you know anything about this Chinese vaccine?"

"I think it has inactive or killed virus in it"

"Really?"

"Thats what I heard. They try wake up our immune system by providing weak virus" 

"I think mRNA vaccine is the best!"

"I dont think so. I think Astrazeneca - oxford vaccine is better for practical purposes and it is cheap. Countries like India  can easily afford"

"They say it is 60-92% effective. Such a wide range!"

"I would take it as 60% effective."

"Well"

"What do we know about Johnson and Johnson vaccine?"

 "I just heard, some segment of DNA of viral genome is inserted in Adenovirus 26,"

"Is that similar to sputnik and oxford vaccine?"

"I need to compare and see the difference. But this vaccine you need only one dose"

"Are they ready for FDA approval?'

"I think they are in the final stage of phase 3 trial May be it will be approved in few months?"

-to be continued

Relax please

மீ டூ காலம்! என்னடி எப்படி இருக்க? (48)

 நிலையாமை!

 இப்போ என்ன அவசரம்?  மாஸ்டர் ரிலீஸ் பண்ண?

 கொரோனா வைரஸ் ஆட்டிப் படைக்கும் இந்த நேரத்தில்!!

கொரோனா வாக்சின் எல்லாம் எல்லாரும் எடுத்த பிறகு ரிலீஸ் பண்ணலாமே?

இருந்தும் என்ன அவசரம்?

 இல்லண்ணா.. இந்த கந்து வட்டிக்காரன்..

 பிரச்சினை என்னனா செலவழிச்ச காசுக்கு வட்டி எவ்ளோ? கந்து வட்டிக்கு வாங்கிதான் படம் எடுக்கிறாங்க. போட்ட காசையாவது எடுப்போம் இலாபம் எல்லாம் வேணாம். இல்லைனா வட்டி நம்மள சாப்பிட்டு விடும் என்பதுதான் காரணம்.

நிச்சயம் பிகில் விலையில் பாதி விலைக்குத்தான் இந்தப்படம் விற்கப்பட்டு இருக்கும். ஓவர் சீஸ் மார்க்கட் ல 50% கலக்சன்தான்

ஆந்திரா கேரளா கர்நாடகால எல்லாம் பாதி விலைக்குத்தான் விக்க முடியும்? அதனால் படம் அல்ரெடி விநியோகஸ்தர்களுக்கு போட்ட தொகையை தந்துவிட்டதாம்

எவன் நெனச்சான். கொரோனா வைரஸ் பாதிப்பு ஏற்படும்னு

வாழ்க்கையே நிலை இல்லாத ஒண்ணுதான்.

சமூகப் பொறுப்பு இவனுக  தாலினு  சொல்லிக்கிட்டு திரிஞ்சவனுக்கெல்லாம் பணம்தான்டா இந்த நாய்களுக்கு அவசியம், மத்ததெல்லாம் ரெண்டாவதுதான் னு போட்டு ஒடச்சிருச்சு நம்ம கொரோனா வைரஸ்!!

***********************

"Hi!"

"Tell me"

"It came out negative, Caro darling"

"I knew that. You were just fucking with me"

"Nope, I did not! It is better to get that tested. Right?"

"Of course. By the way, we will be getting vaccinated soon!"

"Yeah, I got an email saying that we can get vaccinated in a week or so"

"Me too!"

"Well first one is just make your B cells to wake up. We will be protected only after a week of the second dose, the booster shot. That would be a month from now."

"Later is better than never"

"Of course. I hear lots of people do not want to get vaccinated. People working in the nursing home in OHIO  dont want to get vaccinated. I wonder why?"

"I dont know, It is crazy"

"We will be getting pfizer vaccine, I believe"

"Yes! mRNA of the spike protein huh"

"So, it will get translated to spike protein in our ribosome?"

"Yep. Our B cells will start making antibodies against the spike proteins. Those antibodies will fight against the corona virus which has spike protein on it"

"Why cant we inject spike protein itself?  Why m-RNA of spike protein?"

"I really dont know. You need to look it up!" 

"I love biology. It is sexier than your ass, Caro!

"Ha ha ha. You can only marry my ass. Not the biology, no matter how sexy it is"

"Anyway I tried to look it up, but could not find any answers for why cant they use spike protein itself as the vaccine"

"Seems like nobody is as crazy as you are. Only you care about all these"

"Hi I care about your ass too!"

"That's selfish too"

"WHY?"

"Because if I am happy, you would be happy too!"

 "Can I come over there to your place"

"What if I say "No! you cant come now" Will you listen?"

"I will come anyway. I wont listen to what your mouth says.  I know what your heart says"

"lol, Then why do you ask my permission?"

"Idk, I just want to tell you that"

"I like surprises"

"OK, I will be there soon"

***************

"Oh my God Caro! Where did you get this!"

"I got it from Vani"

"Who is she?"

"Another Indian girl. Suneeta introduced her to  me. She is nice"

"Is this her Saree?"

"Yes. She said I can have it for free"

"Really? Not wearing any blouse? Tops?"

"Ha ha ha Just  bra"

"Do you wear petticoat  under the Saree?"

"Of course, she gave that with the Saree"

"Panties?"

"Ha ha ha, You need to find that out!"

"You can not go out like that topless"

"I m not going out. It is just for you"

"You are crazy"

"How do I look?"

"I cant say. Do one thing, Let me take a photo with Saree on. And take one another after you take off all your clothes so that I can compare both and tell you which one looks better?"

"Lol. With Saree and a naked photo? You want to compare my look?!"

"Yes!"

"Can you close your eyes and take that photo?"

"Thats impossible!"

"I wont let you then"

"Come here! My God, you look beautiful darling!"

"Marry me, then!"

"Let us get married once you become pregnant!"

"I really don't care"

"What if I dump you once you become pregnant?"

"That's my problem. Right?"

"I hear that once we get married we wont be attracted to each other anymore"

"Thats bullshit"

"I heard that"

"Let us get that tested then"

"Test what?"

"Whether you fuck me less or more after you marry me?"

"What would be your guess"

"I will say, NO every day so that you will rape me?"

"Why?"

"I dont know. I want to get raped by you"

"Are you all right? I think your hormones are up regulated"

"How would you test that?"

"Let me kiss you first?"

"Where?"

"Hold on darling! In your neck, cheek, lips"

" And?"

"I thought you like surprises"

"Yes"

-to be continued.