Showing posts with label USA. Show all posts
Showing posts with label USA. Show all posts

Thursday, June 25, 2020

என்னடி எப்படி இருக்க? மீ டூ காலம் (21)

கதைக்கு சம்மந்தம் இல்லாத முன்னுரை:

அமெரிக்காவில் கொரோனா வைரஸ் ஆக்டிவ் கேஸ்கள் அதிகமாகிக் கொண்டேதான் போகிறது, சாவும்தான், ஆனால் நியூ யார்க்ல இப்போ ஓரளவுக்கு ஸ்டபிலைஸ் ஆன மாதிரி இருக்கு. மற்ற மாநிலங்களில் அதிகமாகி இருப்பதால் மொத்தத்தில் அமெரிக்கா நிலைமையில் மாற்றம் எதுவும் தெரியவில்லை.

இந்தியாவில் இப்போ ஒரு நாளைக்கு 350-400 பேர் சாவதாக கணக்கு காட்டுறாங்க. இது அமெரிக்காவை கம்ப்பேர் பண்ணும்போது ஒண்ணும் பெரிய விசயமில்லை. இருந்தாலும் இறப்பு அதிகமாகிக் கொண்டேதான் போகிறது

அமெரிக்காவை இந்தியர்கள் பலரும் கேலி செய்றாங்க. என்ன காரணம்னு தெரியவில்லை டெத் டரேட் அதிகமாகத்தான் இருக்கு இங்கே. அதனால் கேலி செய்தால் அதை கேட்டுக்கொண்டு போயிடுறதுதான் சரி. சப்போஸ் இதேபோல் இந்தியாவில் அதிகமாக சாவு இருந்து இருந்தால்,  அமெரிக்கர்களும், இங்கிலாந்து நாட்டுக்காரகளும் இந்தியாவை கேலி செய்யத்தான் செய்வாங்க. எளியவர்களை வலியவர்கள் மட்டமாப் பார்ப்பதுதான் இயற்கை. எல்லாரும் மனிதர்கள்தான். இது மனித இயல்பு.

சைனா இந்த வைரஸை எங்கிருந்தோ பிடிச்சு கொண்டு வந்து, உலகிற்கே தானம் செய்துவிட்டார்கள்.  முதலில் சைனாவில் ஆரம்பிக்கும்போது இது இந்தியாவை இந்தளவுக்கு தாக்கும்னு யாரும் எதிர்பார்க்கவில்லை. போற போக்கைப் பார்த்தால் இந்தியாவில் இது இன்னும் பரவுவதை தடுக்கவே முடியாது போல்தான் இருக்கிறது.

-----------------

"Caro! I found a way to keep life interesting"

"How is that?"

"Just live. Dont worry about nobody"

"Ha ha ha. Can you?  just live like that?"

"I am planning to"

"Idt you can"

"Why not?"

"That's not what you are"

"Let us see. Let us go to year 2090"

"You and I would be dead then"

"Yes but people will be busy making money, impressing others, making love, some will act smart, some will be gullible. Nobody is going to care about you and me. It will be depressing if you come see this world without us"

"I am sure, it will be depressing if you could see this world but you can not see. So, dont worry"

"I wonder why we want to live? Whats wrong in just dying. We dont make a big difference by living little longer. Right?"

"We may make a difference"

"I was reading this cancer biology book. Cell signaling, mitosis, proto oncogenes, oncogenes, tumor suppressor genes and telomere shortening as we get older"

"What did you learn?"

"Death is approaching us as we get older and older. It is a natural process. We just have to live with that."

"Dont we all know that?"

"Not true, if people start thinking about death, they wont be greedy, they wont run after money."

"Thinking about death is not going to help"

"So?"

"Dont think about it. Just live"

"Here is what I learned, when we get older, our telomeres get shortened. Some proto oncogenes like ras gets activated and becomes oncogene and gets activated to do more cell proliferation. Some tumor supressor genes  like retinoblastoma, p53 are getting deactivated. Now cancer cells start growing wherever possible. They find a way to survive and that leads to our death, eventually. But they die when we die too. They can not survive without us being alive"

"Thats interesting"

"What is?"

"They generally say, cancer cells try to survive and immortalized"

"You need to go further, Caro. They die when we die. They are not immortalized"

"Why did you read this?"

"Idk, I could download it for free from some archive"

"ha ha ha"

"I guess I should not have read that. There is nothing positive there. Biological processes are so complex. It is impossible to tune them for our advantage"

"They do do that. Right?"

"We barely hit the target. We can not beat the nature"

"Then we should just die without a fight?"

"Well, Idk, I think a lot these days. Have you watched birds?"

"Yeah. What do you mean?"

"In the spring they start building the nest, lay eggs, and protect them incubate them, have their kid birdies and feed them and let them grow strong. Once they become adult, they literally kick them out and they just act like strangers to them. They dont love them anymore. They hardly realize they are their kids. They lay eggs again...It goes on"

 "What is the point?"

"Idk. It is funny why everyone wants to reproduce including viruses, cancer cells, birds? WHY?"

"I dont know. But I see what you mean."

"I realized one thing, it is hard to answer to the question "Why?" "

"Why is that?"

"It is because we dont know the answer for lots of things, both in Science and in non-science too. We know very little even after living a long life then when we are dying, we still know very little"

"It is not just you dont know? Why do you think nobody knows?"

"You know what is funny?"

"What?"

"People who think they know everything are the #1 idiots in the world. They are so stupid that they could not even realize that. But the irony is that being ignorant or stupid is the best way for survival."

"So, you want me to be stupid or what?"

"Check this out. When I am watching a worm is eaten by Robin, I really feel bad. Also, when a little bird was caught by Hawk I get angry. But."

"But, what?"

"Now I look at myself. What did I eat today? Chicken? Milk? Meat? How do I get them? Someone killed a chicken or goat or cow and brought them to me. Someone stole milk from cow. Now I am no better than a tiger or a Robin or a Hawk. I am doing the same fucking thing everyday for my survival. What a filthy hypocrite I am?"

"Oh my God. We are no better than anybody!"

"Absolutely. But we never think about what we do for our survival. We look at what a Hawk does for its survival. Nature is cruel. It is not beautiful"

"Honestly, I dont think like this"

"May be that is why you are happy. I think about turkey when people celebrating thanksgiving. How many turkeys are getting killed on that day? Poor birds"

"If we care about turkey, we cant have thanksgiving dinner"

"If you care about other beings, you can not survive or live in this world. So, somehow do all the fucking sins, and create a fucking God, and design a "system" or "religion" to do justify whatever fuck-up you do for your survival"

"You deserve something big for a lecture like this"

"Like what?"

"Like this?"

"How do you become so sexy all of a sudden? Shaking your ass?"

"May be I am horny. I am trying to seduce you for my needs"

"You just do it naturally? Once your needs are done, you will dump me like trash"

"You know what?  Your philosophical lecture or this kind of annoying attitude does not turn me off."

"How about cancer biology?"

"Fuck it"

"Why? You want to live ignorant?"

"Of course. I dont think about death when I am cumming."

"You are talking dirty. You must be horny"

"Can I seduce you?"

"You cant"

"Of course I can. It is easy. All your philosophical bull shit will go to drain, when I flash my ass. You will be tempted to grab it"

"Are you using me, Caro?"

"May be"

"I was watching the "weeds" show in netflix. It starts out good but when it goes on, it is no better than any Indian serial. Artificial bullshit. No logic, nothing. They just create characters and get rid of some. Nancy becomes a big slut. Idk what the fuck this show is all about.They say they do everything for protecting family? What a joke!"

"Jenj Kohan? Orange is the new black creator?"

"Yeah, Jenji-fucking-Kohan! She is sick for sure."

"ha ha ha"

"I am serious. She is really really really sick. Breaking bad is far better than this fucking weeds show"

"May be girls will like this"

"I doubt it."

- to be continued

relax please!







Monday, June 1, 2020

என்னடி எப்படி இருக்க? மீ டூ காலம்! (20)

கதைக்கு சம்மந்தம் இல்லாத முன்னுரை:

அமெரிக்காவில் கொரோனா வைரஸ் கேஸ்கள் இன்னும் அதே போல்தான் தொடர்கிறது. 104000 இறப்புகள். 1.7 மில்லியன் பாசிட்டிவ் கேஸ்கள்.

மக்களால் அடைந்து கிடக்க முடியவில்லை. வெளீயே வர ஆரம்பித்து விட்டார்கள். கொஞ்சம் கொஞ்சமாக எல்லாவற்றயும் திறக்க ஆரம்பித்து விட்டார்கள். மறூபடியும் அதிகம் பரவும் என்பது தெரிந்தும், மக்கள் வெளீயே வர்ராங்க.

வாஷிங்டன் ஸ்டேட்லதான் அமெரிக்காவில் முதன் முதலில் அதிக கேஸ்கள் இருந்தது. அதிக உயிரிழப்பும் ஏற்பட்டது. ஒரு மாதிரி பீக் கை அடைந்து இப்போ ஓரளவுக்கு சரியாகிவிட்டது. இதுபோல் எல்லா மாநிலங்கள்லயும் ஆகும் என்பது தெரிந்தாலும் யாருக்கும் பொறூமை இல்லை. விஞ்ஞானிகள் சொல்வதெல்லாம் யாரும் கேட்பதாக இல்லை.

சைனாவில் மட்டும் 83,000 கேஸ் கள், 4,600 உயிரிழப்போட நின்றூவிட்டது போல் கணக்குக் காட்டுறாங்க. இதை யாரும் நம்பவில்லை.

இந்தியாவில் இப்போ அதிகமாகிறது. இருந்தாலும் அமெரிக்கா நியூஸ் தான் இந்தியாவில் பார்க்கிறாங்க. என்ன இப்படி அமெரிக்காவில் சாகிறாங்கனுதான் ஒரே "கவலை"!

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"I think we all are going to get infected by this Coronovirus, Caro!  It is like oxygen. The virus is everywhere. Impossible to escape"

"Yeah, it is quite possible, we all will get infected if not today, may be  tomorrow or six months from now."

"Some of us will make it and some will have to die"

"The lucky ones?"

"Ha ha ha You mean people who die are lucky?"

"Did I say that? You are saying that."

"No, I am really wondering who is lucky? The one who is going to die or one who is going to recover?"

"Dont you think the people who recover are lucky?"

"I dont know. You think after this "corona lesson" they will become different people once all this over? Or they will go back to "the same" again?"

"They might get better."

"I don't know. People will not change, Caro. Have you seen "Unforgiven"?"

"Of course"

"Remember, William Munny will get flu and will be almost dead? But, once he recovers, and become normal again, he will continue his "murdering business". That's what people really are. People don't change, Caro"

"You are becoming cynical"

"No, I am always cynical."

"Thats not true. Not when you were a child. Right?"

"How would you know?"

"Children are simple-minded. They become like you once they grew up"

 "You know who will get the credit when they come back alive?"

"Who?"

"The God!"

"Ha ha ha. What if they die?"

"I guess God will get credit for that too"

"Probably not. May be Satan?"

"So, Satan outfights the God sometimes?"

"I dont know"

"I am sure he does"

"It is not God's fault that hey give all the credit to him. Right?"

"Of course not. He does not exist. How will anything will become his fault?"

"Ha ha ha"

"I was thinking Why Americans are not able to control this virus by "behaving"?"

"And?"

"Suppose, you tell them, if you want to live, there is only one condition. That is, you should not have sex!"

"Ha ha ha"

 "You know what will they do? I think will fuck for one last time and die rather than living"

"Ha ha ha"

"I am serious. That's what we are"

"It is funny too"

"America does not have Buddha or Jesus"

"What do we have?"

"Bunch of business-minded people and conservative politicians who run this country and of course porn and alcohol"

"America also has you and me. Are we not sensible people?"

"I am talking about the bigger picture. See once they reopened, look at the beach and lake of ozark. People just dont care anymore about social distancing. This is what we are. We are not good enough to handle this kind of situation. If two people follow the rules and thousands don't, what will happen?"

"We lose, I guess"

"I think this virus outfights us!"

"I dont understand. Why the death rate is so high in US, UK, Spain, Italy and France? It is not as high in India?"

"India has a pretty warm weather. May be the virus is less aggressive in warm weather? Texas and California are doing better than New york and Illinois."

"Yeah Texas dont have that many deaths. It is a big state with huge population. May be because it is warm?"

"May be. The death-rate is relatively low in India and countries which have warm weather"

"It is possible it may have got mutated to another virus in warm weather and which is not that deadly?"

"Idk,Caro. Let us understand some virology. Caro! You are the master! According to Baltimore classification, what type of virus is this?"

"This belongs to type IV, I believe. The genome has (+ve)- single-stranded RNA in Coronaviruses"

"So, it is an RNA virus. Just like HIV? Genome has single-stranded positive-sense RNA just like HIV"

"Not quite, HIV has reverse transcriptase as well but Coronaviruses do not have that enzyme. HIV is classified as type VI "

"Why is that?"

"HIV has (+ve sense) single-stranded RNA as well but it is a retrovirus, Coronavirus is not a retrovirus. They replicate in a completely different manner"

"Though they both have positive-sense RNA as their genome? How are they different? Their target cells are different, that I know"

"Yeah, HIV targets helper T cells,  those are immune cells or a kind of white blood cells but Coronavirus targets lung cells and bronchi."

"And How they replicate?"

"Coronavirus replicates just like poliovirus but it gets into lung cell, not muscle cells. As soon as it gets into cytoplasm, it releases its single-stranded RNA. The RNA acts just like a messenger RNA. It will be taken to Ribosome and get translated to proteins necessary for making new daughter viruses. Not only that it has an enzyme called replicase, it will make a -ve sense RNA strand which is complementary strand of genome (+)-ssRNA. Then the negative strand  ssRNA will be used as a template to make +ss-RNA genome. It can not muliply its positive sense ss-RNA without making complementary - sense ss-RNA"

"So, it never gets into nucleus at all? Does not make DNA? Does not integrate in our chromosome at all"

"That is correct. It does not. At least for replication."

"How about HIV?"

"HIV enters helper T cells (a kind of white blood cells) just like Corona virus. Once it get into cytoplasm, reverse transcriptase, makes a complementary (-ve sense) DNA using this +ssRNA genome. Then that DNA used as template to make a complementary DNA strand. Once it makes both strands of DNA which is a "copy" of its genome in a DNA form. It is taken into our nucleus and an enzyme called inegrase, inserts the DNA piece into the chromosome (DNA) of helper T cell and it will get transcribed and make all the necessary proteins and the ss-RNA genome and all the enzymes such as reverse transcriptase, hiv protease, integrase to make daughter viruses. It will make lots of them and then eventually the helper T cell will not be able to survive and dies"

"Thats beautiful. The way they invade our cells and makes more of their children!"

"Beautiful? You are crazy!"

"Look at as a natural process. Dont act like a normal selfish human being, Caro! It is beautiful like your ass movements when you walk around"

"Really?"

"The pity is only I can watch it!"

"Ha ha ha"

-to be continued


Relax please