மீ டூ காலம்! என்னடி எப்படி இருக்க? (45)

Breaking News! US Republican congressman Luke Letlow dies of Covid-19 complications. He was 41 year old. He was tested positive 10 days ago. Moved to ICU a week ago. Today he died. He was a healthy 41-year old man! He had a wife and two beautiful children.

This is why this virus is scary!

Trump and Republicans never forced people to wear mask and did not avoid big rallies. Well, some never learn no matter what happens.

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Astrazeneca-Oxford vaccine approved today in UK! 

May be, before the end of this week, UK people will get vaccinated. India would approve that as soon as UK did.

This vaccine is based on Adenovirus, not based on mRNA. Thats appropriate for India because it is more stable. 

mRNA or any RNA are highly unstable macromolecules. DNA is much more stable than RNA because it lacks a 2-prime hydroxyl group. What? What is that? RNA has a sugar called ribose which has a OH group at 2-prime position. But DNA does not have that. It has 2-prime deoxy ribose. The lack of 2-prime OH group  gives lot of stability to DNA. To understand what I am saying you need to know, chemistry, biochemistry and biology as well.

I suspect even paappaan nanthavanathaan  would understand because biologists lack basic chemistry knowledge. Especially biologists in India. Who the fuck he is? Dont worry! A sneaky paappaan! Living in US as a "slave" under the beef-eating bosses  

If you do not have that background it is hard for you to follow what I am saying here. Hold on! That does not make you inferior or anything like that. It is not your area. You may be coding and making big bucks! Life is all about how much fucking money you make. Right?

Now, Dont think paappaan Sujatha or Kamal haasan can understand what I am talking about (DNA vs RNA stability etc)  though they/you might claim that they are geniuses. They can not understand that either. Get that in your fucking dead brain! One need to have some biology and chemistry  background to understand some things.

Any way, mRNA are highly unstable and so Pfizer vaccine and moderna vaccine are unstable and need to be stored at dry-ice (-78 C) temperature to avoid decomposition. Thats a big problem for countries like India. Sputnik and Oxford vaccines are not based on mRNA and so they are much more stable. They can be stored at -20C or so. So it can be transported and stored easily. These two are more appropriate for Indian conditions! 

 The bad thing in India is that only rich can afford  this vaccine. Just like by-pass surgery, only rich can afford. But in western nations, almost all citizens are treated equally and can get vaccinated because it is free! It is not really free. They take the tax payers money and use for that! இதுதான் மேலை நாடுகளூக்கும் நமக்கும் உள்ள வித்தியாசம். As MR Radha says, ithu ungka thalai yezhuththu!

இந்தியா இந்தியானு பெருமை பேசுற பார்ப்பானுகளூக்கு நான் சொல்ல வர்ரது என்னனா. இதுதான் உங்க நிலைமை. நீ உலகத்திலேயே அறிவாளினு நெனச்சா, இதுபோல் ஒரு சூழலில் அதைக் காட்டனும். எப்படி? மேலை நாடுகள் கண்டு பிடிக்கும் முன்னால நீயும் ஒரு வாக்சினோட வந்து நின்னு இருக்கனும். அது உன்னால முடியலைனு உனக்குப் புரியனும். ஆனா இதெல்லாம் உன் மரமண்டையில் ஏறாது. இருந்தும் ஏன் சொல்றன்னா நம்ம ஊரில் பார்ப்பானுக்கு  உருவிவிடும் திராவிட கைக்கூலிகள் திருந்தனும்.

 இதிலே என்ன அதிசயம்னா, சைனா கூட ஃபைசர் வாக்சின் வாங்கி பயன் படுத்துறாங்க!! ஜப்பான் மற்றும் பல மேலை நாடுகள்கூட. அமெரிக்கா ஏன் தன்னை உலகிலேயே தலை சிறந்த நாடுனு சொல்லிக்கொள்கிறதுனு கேட்டால், இது போல் காரணங்கள்தான்.

ஒரு நிமிடம்! I am not bragging because I happened to live in US. All my relatives live in India just like you are!

நான் இன்னும் வாக்சின் போட்டுக்கவில்லை. அதாவது என் டேர்ன் இன்னும் வரவில்லை. அனேகமாக இன்னும் ரெண்டு மாதம் ஆகலாம். இந்தியாவில் உள்ள பணம் படைத்தவர்கள், எனக்கு முன்னாலேயே ஆஸ்ட்ரா ஜெனெகா அல்லது ஸ்பட்னிக் வாக்சின் எடுத்துக்க வாய்ப்பிருக்கு. பண அடிப்படையில் எல்லாம் அமெரிக்காவில் வாக்சின் ப்ரையாரிட்டி கொடுக்கப் படுவதில்லை. இந்தியாவில்தான் அது போல் வசதிகள் இருக்கு! இதை எல்லாம் உங்க மரமண்டையில் ஏற்றிக் கோங்க!

The bottom line is, we could not come up with a vaccine. We depend on western scientific and medical achievements but we never accept that! I wonder why??? இதுக்கு காரணம் என்னனா ..அது இதுனு சப்பைகட்டுவானுக நாதாரிகள். வாய்க்கு மட்டும் கொறச்சல் இருக்காது.

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இந்தியா நினைவுகள்..

என்ன தம்பி எப்போ வந்தீங்க? நல்லா இருக்கீங்களா? னு விசாரிப்பார் நம்ம செல்வகுமார் அண்ணன். எந்நேரமும் போதைலதான் இருக்கும் அண்ணன். ஆனால்  மக்களின் தரம் தெரியும். நம்ம தெருப் பையன் பெரிய படிப்பு ஏதோ படிக்கிறான்னு ஒரு அன்பு மரியாதை. ஒரு பிரச்சினைனா முதல் ஆளா வந்து நிக்கும்.

உடனே இந்தியாவை மிஸ் பண்ணூறேன்னு நெனச்சுடாதீங்க. இதெல்லாம் அந்தக் காலம். இப்போ எல்லாம் எவனும் எவனைப் பத்தியும் கவலைப் படுவதில்லை. சம்மந்தா சம்மந்தம் இல்லாதவன் எல்லாம் வந்து  தெருவில் குடியிருக்கிறானுக. பூர்வீக சொத்து வச்சிருந்தவன் எல்லாம் எங்கேயோ போயிட்டான். 

கள்ளக்காதல், செல் ஃபோன் காதல் எல்லாம் மலிந்து கெடக்கு. எல்லாரும் பிசியா இருக்கானுக. உக்காந்து ஊர் கதை பேச எவனுக்கும் நேரமில்லை. முன்னேறிட்டானுகளா இல்லை நாசமாப் போயிட்டானுகளா னு தெரியலை.

அமெரிக்கா வந்த புதிதில்..

இருந்த இடம் ஒரு காலேஜ் டவுன். தெரிந்தவன் தெரியாதவன் எல்லாம் ஹல்லோ சொல்லுவானுக. யாருனே தெரியாது, எதிர்த்தாப்பிலே பார்த்தால் ஹலோ சொல்லுவாங்க. புரியாத கல்ச்சர். என்னனு கேட்டால் எதிர்த்தாப்பிலே ஐ கான்டாக்ட் பண்ணூம்போது ஹலோ சொல்றதுனாலயோ, ஹவ் ஆர் யு டூயிங் திஸ் மார்னிங் னு கேட்பதில் ஒன்னும் பெரிய தப்பில்லைனு சொல்லுவாங்க. உடனே அமெரிக்காவில் எல்லாரும் இப்படினு நெனச்சுடாதீங்க. 

இன்று

சைட் வாக்ல நடக்கும்போது மாஸ்க் போட்டிருந்தாலும் எதிர்த்தாப்பிலே எவனாவது வந்தா.. நம்ம எதிரி வர்ரான்னு சைட் வாக்கை விட்டு இறங்கிப் போவேன்.  

மாஸ்க் போட்டு இருப்பதால் எதிர்ப்பாலே வர்ரவன் முறைக்கிறானா இல்லை புன்னகைக்கிறானா?னு பலருக்கு புரிவதில்லை.

ஆக இந்த வைரஸ், மனிதனுக்கு நல்ல பாடம் புகட்டி இருக்கு!

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"Caro! This virus is already started getting mutated to another strain it seems! I think the mutant is now everywhere already"

"I think it is normal. Viruses get mutated easily"

"Why is that?"

"What they say is, viruses replicates faster. As they are rushing their replication, it is easy to make mistakes and those mistakes cause mutation and so easily get mutated"

"Hmm. Are you making up this story, Caro?"

"No! It is true. Here is a reference for you in PLOS, check this out!  https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000003"

"Tell me what is in it?"

"This is what they say "RNA viruses have high mutation rates—up to a million times higher than their hosts—and these high rates are correlated with enhanced virulence and evolvability, traits considered beneficial for viruses." blah blah"

"It is beneficial for the viruses? Meaning it is bad of us?"

"Of course, they mutate for better survival. More they survive, more trouble for us. So they can kill us easily"

"This virus must be formed from another virus? A mutant of another virus. Right?"

"Of course. Covid19 did not come from nowhere. It should be a mutant of another virus. They say, its "parents" of covid 19 used to attack "bats". Now after some mutation, the daughters namely coronavirus-2, a mutant form of bat virus started attacking human cells. They are everywhere in the planet."

"Can't they make a bad mutation that will lead to their extinct? In other words the mutant version is less harmful to us? Our cells can kill them easily?"

"It is possible but usually the mutant will have better survival rate. Some mutant might not survive. Such mutant viruses die easily and so we dont even notice them.  The surviving ones are stronger. Meaning, they can kill our cells easily"

"Explain me what is a mutation, Caro? What is an original covid-19 and what is a mutated covid-19"

"That is your area You explain me"

"Mutation is my area? My area is your ass only!"

"Lol. Too bad, you cant publish that research anywhere"

"OK,  Let us say, spike protein of covid-19 has M-A-D-Y-W-R---------P-E-S as amino acid sequence. Mutant spike protein sequence would be M-A-D-Y-W-R---------P-V-S. Glutamate (E) is changed to a Valine (V) in the mutated virus.

"You know one-letter code for all amino acids?! What is an A?"

"Caro's ass!"

"lol"

"Fuck you, Caro! Are you checking my on amino acids knowledge?"

"Answer my question, mister!"

"Alanine, bitch"

"What is P?"

"P is Caro's Panties"

"lol, I thought you would say something else"

"OK, P is proline"

"How about B?'

"No amino acid has B, bitch!"

"How about "O"?

"Ornithine?"

"Is that an Amino acid?"

"Of course. Go, read Urea cycle again"

"But that is not in the Proteins"

"So what? Ornithine is a natural amino acid. Very analogous to Lysine"

"I dont think Ornithine has one letter code as "O"?"

"Why? no white man named it, Right? Fucking whites!"

"lol"

"3-Hydroxy and 4-hydroxy Prolines are all in Proteins like Collagen. But they do not have one-letter code either"

"True"

"Some white guy has to address that issue too. Then only this fucking world would listen"

"Are you better than whites?"

"Of course"

"You are better in bed I know, but  not in everything"

"Anyway,  A-D-Y-W-R---------P-E-S is the amino acid sequence in Spike Protein. What is the codon for Tryptophan?"

"Have you memorized that too?"

"No, not yet. I have to look it up"

"Good. You make me feel better now"

"Hey I was teaching this student, chemistry"

"Girl or guy?"

"It is a guy! How does it matter?"

"It does to me"

"Anyway, he had problem figuring out the Electronegativity trend in periodic table. I said, You have to start from F, fluorine. That's the most electronegative atom in the periodic table. You can go only one way from there in the periodic table, it will have to decrease whether you go the left or down in the periodic table"

"I see. Start from Fluorine, huh?"

"I told him, Always remember, you have got to start from F like in Fucking! He was laughing for ever! Even now, when I text him for something, he will say I will never forget Fluorine is the most electronegative atom. F like in Fucking!"

"That's hilarious"

"Now he knows how to see the trend of electronegativity in a periodic table. That's the whole point"

"Dont tell that to girls"

"I can tell that to only one girl, namely Caro!"

"Do you flirt with them? The girls you teach?"

"I dont know. You should ask them"

"What's her name? You taught her organic chemistry? A premed student or something?"

"That was Fatima! A muslim girl"

"I thought they are very sensitive. You need to be extra careful with them?"

"Idk, I correlate chemistry with real life so that they can remember easily"

"Like what?"

"It was funny. I was teaching kinetic control and thermodynamic control to his girl, Fatima. But She was keep asking me how to remember that..blah blah I told her, OK, Kinetic control is like one has a crush on someone. One is attracted to him or her. It is very quick decision, it is fast but most of the time it wont last long. It is like a short-term relationship . Thermodynamic control is like you interact, get to know that person, there are ups and downs in the relationship. and finally decide that that guy is worth marrying and you go on with a long-term relationship"

"What did she say?'

"She was giving me sarcastic look and said, I GET IT now with a smile"

" Then?"

"I was not sure whether that was an appropriate correlation but sometimes I do that"

"Did she continue the sessions with you, afterwards"

"Of course. I taught her orgo 1 and orgo 2 as well. She got an A in both of them. She may be in medical school now"

"Was she bright?"

"Of course. She was a bright student"

"She is from middle east?"

"Yes, her parents are from middle east and they kind of settled here in US"

"How did you come to know her?"

"Her mom contacted me through online tutoring site. She was telling me that her daughter has difficulties with orgo and she is very bright blah blah. I said, let me see. Let me talk to her. She said that she prefers to meet in a common place like library or starbucks. I said, OK"

"You said she was bright"

"Not all bright students can study organic chemistry. Lot of bright students will have difficulties because it is different kind of subject. Bright students wont like it"

"Seriously? Was she cute?"

"I really dont care, Caro. What matters most is her learning style. If it clicks well, look hardly matters. A not-so-good-looking girl will look beautiful if she appreciates and understands what I teach her"

"Really?"

"I tried to teach couple of kids,who are my friends' friends' daughters or sons.It never clicked with them"

"What do you mean?"

"Idk, I never could have had any pleasure teaching them so far"

"Because?"

"They dont catch the important points I teach them. They answer in a weird way. Though the answers are correct, they dont please me. The point is students' look hardly matters. Neither do gender, race or language the student speaks matter"

"So, all that matters is the students learning style.  I dont believe it!"

"I know but it is true!"

"Do they say hi to you? Fatima?"

"They just move on. When they finished organic and get into medical school or whatever, they will just move on."

"Really?"

"I connect with some people through linkedin. Now we got derailed? Where were we?"

"Mutation?"

"Yeah. Where did Coronavirus come from?"

"There is a virus which infect bats and that got mutated to another virus which is attacking humans now!"

"Mutation is everything?!"

"Thats how we evolved. Right? The more I read, I come to the conclusion that it is hard to control the natural selection. One virus can erase us ALL! We are nothing. Why are we having all this ego??!"

"Ignorance!"

"Come here"

"Yes?"

"You smell good, Caro!"

"OMG! You are smelling my neck and arm pit. I think your hormones are up regulated"

"You smell good darling"

"Really?"

"Yeah, mine is up. How about your hormones level now?'

"Kiss me, you would know from my response!"

"Where?"

"In my cheeks"

"Why? Are you wet in every tasty spots?" 

"Ha ha ha  Probably"

"I can tell your hormones level only by tasting your saliva"

"Ha ha ha Really?"

"The taste of your saliva tells me your hormone level"

"So, you want to kiss me in my mouth or you want me to spit in your mouth?"

"Both works with me! It works better if I lick your tongue"

 "What are you really?"

"Why?"

"You know how to make a woman come without even touching them"

"You also know how to turn me on by complimenting like this, darling"

-to be continued